Q2. Once print settings are configured, do they need to be re-configured before being used again?

A2. Print settings do not need to be re-configured.

Refer to the following.

PS Plug-in driver:

Use [Favorite Setting] to save the print settings that you configured. Once the print settings are saved, they can be called at any time.
For details, refer to Using Favorite Setting.

PPD driver:

If the print settings are registered as the default settings of the printer driver, they are applied to all applications.
For details, refer to Registering the Default Settings.